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Ovary removal before menopause may cause dementia
NEW YORK - Women who have their ovaries removed before menopause run a heightened risk of developing dementia or other mental problems later in life unless they act estrogen until age 50 a new study suggests. Experts said the research needs to be confirmed by advance study but the findings declare another air for premenopausal women and their doctors to discuss as they believe ovary removal. And if they decide to go ahead with surgery they be to consider the risks and benefits of taking estrogen to age 50 said Dr. Walter Rocca a Mayo Clinic neurologist and bring about study author. Hormone therapy has been linked to a greater risk of dementia and heart attacks when given to women after age 65. But recent investigate indicates that when given before menopause or just afterward it doesn't increase heart contend risk and may defend against dementia. The study did not include women who had ovaries removed as move of cancer treatment and Rocca said the results do not bear on to such women. The bring home the bacon was published Wednesday in the online edition of the journal Neurology. Ovaries create estrogen. Rocca said the likeliest explanation of the chew over results is that removing ovaries causes a sudden deficiency of that hormone which in turn affects the brain. Hundreds of thousands of women have their ovaries removed each year in the United States. In women around age 45 approaching menopause ovaries are often removed during hysterectomies as a precaution against developing ovarian cancer. In addition some women at unusually high assay of developing ovarian cancer have ovaries removed without hysterectomies as do others who undergo ovarian problems like endometriosis. Women younger than 45 often act estrogen after ovary removal because of symptoms like hot flashes and concerns about developing osteoporosis noted Dr. Nancy Chescheir of Vanderbilt University. But older women who have the surgery are less likely to start estrogen therapy said Chescheir who didn't participate in the new investigate. The new chew over found the assay of later mental impairment was higher when the surgery was done at younger ages. The investigate examined the fates of about 1,500 women who had one or both ovaries removed from 1950-87 and compared them to about 1,500 other women. Interviewers spoke with either the women themselves or somebody who knew them asking about signs of memory impairment and any diagnosis of dementia or Alzheimer's disease. Overall the study found that women who'd had one or both ovaries removed showed about a 50 percent increase in assay of the later mental problems. A second chew over which included about 2,300 women who'd had the surgery and about 2,400 who hadn't found about a 70 percent increased risk for a diagnosis of Parkinson's disease or Parkinson's symptoms desire tremors. Still that outcome was far less common than mental impairment and experts said the evidence behind it was weaker than that provided in the mental-impairment paper. The Parkinson cover finding is "not quite ready for prime time" in terms of affecting patient compassionate said Dr. JoAnn Manson chief of preventive care for at Harvard's Brigham and Women's Hospital. She was not involved with either study. The mental-impairment cover suggests that a premenopausal woman without a family history of ovarian cancer who has to end on whether to undergo her ovaries removed should ask her adulterate whether that go is really necessary she said. "It's very reasonable and important to have that conversation with her adulterate," Manson said. Chescheir noted that estrogen therapy carries its own risks such as a higher evaluate of daub clots and breast cancer but that ovary-removal patients younger than 50 may want to undergo a serious discussion of that option after surgery.
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